Synthetic biology is a multidisciplinary field that combines biology and engineering principles to generate new biological parts, modules, systems, and organisms. For example, synthetic promoters and engineered transcription factors can be used for the de-novo construction of artificial genetic circuits with well-defined functions. This approach provides powerful tools to overcome major challenges in a range of applications, such as basic research, biomedicine, ecology, agriculture, biosynthesis, and more. Our lab implements synthetic biology to develop practical biomedical applications, and to decipher human biology. Our versatile platforms could be implemented to treat a range of human diseases and to push forward pioneering research projects.